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Highly Accessed Open Badges Commentary

Measuring glomerular filtration rate in the intensive care unit: no substitutes please

Bruce A Molitoris

Author Affiliations

Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indiana Center for Biological Microscopy, Research Building #2, RM 202, 950 West Walnut Street, Indianapolis, IN 46202, USA

Critical Care 2013, 17:181  doi:10.1186/cc12876

See related research by Bragadottir et al.,

Published: 4 September 2013


Acute kidney injury (AKI), due to its increasing incidence, associated morbidity and mortality, and potential for development of chronic kidney disease with acceleration to end-stage renal disease, has become of major interest to nephrologists and critical care physicians. The development of biomarkers to diagnose AKI, quantify risk and predict prognosis is receiving considerable attention. Yet techniques to accurately assess functional changes within patients still rely on the use of an insensitive marker (creatinine), creatinine-based estimating equations and unreliable urinary tests. Therefore, it is critical that functional tests be developed and used in combination with biomarkers, thus allowing improved care in AKI and chronic kidney disease patient populations.