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Highly Accessed Open Badges Commentary

The gut-brain axis in the critically ill: Is glucagon-like peptide-1 protective in neurocritical care?

Mark P Plummer12*, Juris J Meier3 and Adam M Deane12

Author Affiliations

1 Discipline of Acute Care Medicine, Level 5, Eleanor Harold Building, University of Adelaide, North Terrace, Adelaide, South Australia, Australia 5000

2 Intensive Care Unit, Level 4, Emergency Services Building, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia, Australia 5000

3 Diabetes Division, Department of Medicine I, St Josef Hospital, Klinikum der Ruhr Universit├Ąt Bochum, Gudrunstrasse 56, 44791 Bochum, Germany

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Critical Care 2013, 17:163  doi:10.1186/cc12758

See related research by Bakiner et al.,

Published: 9 July 2013


Enteral nutrient is a potent glucagon-like peptide-1 (GLP-1) secretagogue. In vitro and animal studies indicate that GLP-1 has immune-modulatory and neuroprotective effects. To determine whether these immune-modulatory and neuroprotective effects of GLP-1 are beneficial in the critically ill, studies achieving pharmacological GLP-1 concentrations are warranted.