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Highly Accessed Open Badges Commentary

Steroid responses in sepsis: some novel thinking that may provide new insight

Clifford S Deutschman

Author Affiliations

Perelman School of Medicine at the University of Pennsylvania, Dulles 781A/HUP, 3400 Spruce Street, Philadelphia, PA 19104-4283, USA

Critical Care 2013, 17:147  doi:10.1186/cc12723

See related research by Guerrero et al.,

Published: 27 June 2013


Glucocorticoid use in sepsis is controversial. In contrast to other extracellular signaling molecules, glucocorticoid receptors (GRs) are intra-cytoplasmic. Several GR isoforms have been identified. A study in Critical Care Forum suggests that sepsis alters the abundance of the dominant negative GRĪ². Here we discuss GR isoforms and how they may affect cellular responses to glucocorticoids in sepsis.