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Highly Accessed Open Badges Commentary

A new role for statins in sepsis

Jean-Sebastien Rachoin*, Elizabeth Cerceo and R Phillip Dellinger

Author Affiliations

Department of Medicine, Cooper Medical School of Rowan University, Cooper University Hospital, One Cooper Plaza, Suite 229 Dorrance, Camden, NJ 08103, USA

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Critical Care 2012, 17:105  doi:10.1186/cc11907

See related research by Patel et al.,

Published: 17 January 2013


Several studies have shown promising results regarding the use of statins as an adjunctive treatment for sepsis. Most of those studies were retrospective or observational in nature. The ASEPSIS trial has reported that the administration of atorvastatin reduced clinical progression of sepsis but did not improve mortality. These findings are promising and further multicenter trials are needed to confirm these outcomes and to establish whether this class of medications will offer utility in this regard.