A new role for statins in sepsis
Department of Medicine, Cooper Medical School of Rowan University, Cooper University Hospital, One Cooper Plaza, Suite 229 Dorrance, Camden, NJ 08103, USA
Critical Care 2012, 17:105 doi:10.1186/cc11907
See related research by Patel et al., http://ccforum.com/content/16/6/R231Published: 17 January 2013
Several studies have shown promising results regarding the use of statins as an adjunctive treatment for sepsis. Most of those studies were retrospective or observational in nature. The ASEPSIS trial has reported that the administration of atorvastatin reduced clinical progression of sepsis but did not improve mortality. These findings are promising and further multicenter trials are needed to confirm these outcomes and to establish whether this class of medications will offer utility in this regard.