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Open Badges Commentary

Cell-free DNA and outcome in sepsis

Andrew Rhodes* and Maurizio Cecconi

Author Affiliations

Department of Intensive Care Medicine, St George's Healthcare NHS Trust and St George's University of London, London, SW19 0QT, UK

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Critical Care 2012, 16:170  doi:10.1186/cc11508

See related research by Dwivedi et al.,

Published: 8 November 2012


Severe sepsis can be a catastrophic condition that is often associated with poor outcomes. The early diagnosis and management of the condition are vital in order to improve the chances of survival. However, owing to the syndromal nature of its definition and the lack of a biomarker able to accurately confirm the condition, the diagnosis of sepsis is challenging. Even more challenging is the prediction of how these patients will respond to the therapy and whether they will survive the intensive care and the hospital admission.