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Open Badges Commentary

Measuring glomerular filtration rate in acute kidney injury: Yes, but not yet

Bruce A Molitoris

Author Affiliations

Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Research Building #2, RM202, 950 West Walnut Street, Indianapolis, IN 46202, USA

Critical Care 2012, 16:158  doi:10.1186/cc11482

See related research by Pickering et al.,

Published: 24 September 2012


Acute kidney injury has become a major focus for nephrologists and critical care physicians. The development of structural biomarkers is proceeding, but the results to date have been disappointing. The use of a shortened creatinine clearance as a functional acute kidney injury biomarker is not new but has not been compared with that of other diagnostic approaches. A rapid, repeatable, and accurate measured glomerular filtration rate would be the gold standard for a functional biomarker and is not far off.