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Open Badges Letter

Soluble CD40 ligand, a mediator of sepsis or of transfusion-related adverse effects?

Pieter R Tuinman* and Nicole P Juffermans

Author Affiliations

Department of Intensive Care Medicine and Laboratory of Experimental Intensive Care and Anesthesiology (LEICA), Academic Medical Center, Meibergdreef 9, Amsterdam, 1105 AZ, The Netherlands

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Critical Care 2011, 15:429  doi:10.1186/cc10237

See related research by Lorente et al.,, and related letter by Chew and Thorlacius,

Published: 31 May 2011

First paragraph (this article has no abstract)

Dr Lorente and colleagues [1] report on the interesting association between serum soluble CD40 ligand (sCD40L) levels and mortality in patients with sepsis. Some variables that can influence outcome in sepsis were accounted for in their analysis. However, the amount of transfused blood products, which may influence levels of sCD40L, was not reported.