http://ccforum.com/content/13/4/170/comments The latest comments on the article 'Macrophage migration inhibitory factor (MIF), infection, the brain, and corticosteroids ' 2009-07-28T09:09:54Z http://ccforum.com/content/13/4/170/comments#364642 <p>Dear Editor, <br/> <br/>The authors rightly point out the central role of macrophages in the severe meningitis. They are also the important source of NO associated classically with the dilatation of blood vessels at 4-20 nM concentrations. Larger, 100-340 nM nitrogen oxide concentrations compete with oxygen at the cytochrome oxidase thereby adding a histotoxic component to the inflammation (Antunes et al, 2004). <br/> <br/>Thus, one wonders what all modalities of a treatment aimed at the macrophage functions might be. <br/> <br/>Antunes A, Boveris A, Cadenas E. Proc Ntnl Acad Sci USA. 2004; 101: 16774.</p> Heikki Savolainen 2009-07-28T09:09:54Z http://ccforum.com/content/13/4/170 Geldhoff et al. Critical Care 13 170 Mon Jul 27 00:00:00 BST 2009