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<art>
   <ui>cc5431</ui>
   <ji>CCJ</ji>
   <fm>
      <dochead>Poster presentation</dochead>
      <bibl>
         <title>
            <p>Changes in tissue oxygen saturation reflect changes in targeted oxygen delivery in postoperatively optimised patients</p>
         </title>
         <aug>
            <au id="A1">
               <snm>Hamilton</snm>
               <fnm>M</fnm>
               <insr iid="I1"/>
            </au>
            <au id="A2">
               <snm>Canete</snm>
               <fnm>M</fnm>
               <insr iid="I1"/>
            </au>
            <au id="A3">
               <snm>Cecconi</snm>
               <fnm>M</fnm>
               <insr iid="I1"/>
            </au>
            <au id="A4">
               <snm>Al-subaie</snm>
               <fnm>N</fnm>
               <insr iid="I1"/>
            </au>
            <au id="A5">
               <snm>Vercuil</snm>
               <fnm>A</fnm>
               <insr iid="I1"/>
            </au>
            <au id="A6">
               <snm>Fawcett</snm>
               <fnm>J</fnm>
               <insr iid="I1"/>
            </au>
            <au id="A7">
               <snm>Dawson</snm>
               <fnm>D</fnm>
               <insr iid="I1"/>
            </au>
            <au id="A8">
               <snm>Rhodes</snm>
               <fnm>A</fnm>
               <insr iid="I1"/>
            </au>
         </aug>
         <insg>
            <ins id="I1">
               <p>St George's Hospital, London, UK</p>
            </ins>
         </insg>
         <source>Critical Care</source>
         <supplement>
            <title>
               <p>27th International Symposium on Intensive Care and Emergency Medicine</p>
            </title>
            <note>Meeting abstracts</note>
         </supplement>
         <conference>
            <title>
               <p>27th International Symposium on Intensive Care and Emergency Medicine</p>
            </title>
            <location>Brussels, Belgium</location>
            <date-range>27&#8211;30 March 2007</date-range>
            <url>http://www.intensive.org</url>
         </conference>
         <issn>1364-8535</issn>
         <pubdate>2007</pubdate>
         <volume>11</volume>
         <issue>Suppl 2</issue>
         <fpage>P271</fpage>
         <xrefbib>
            <pubid idtype="doi">10.1186/cc5431</pubid>
         </xrefbib>
      </bibl>
      <history>
         <pub>
            <date>
               <day>22</day>
               <month>3</month>
               <year>2007</year>
            </date>
         </pub>
      </history>
      <cpyrt>
         <year>2007</year>
         <collab>BioMed Central Ltd.</collab>
      </cpyrt>
   </fm>
   <bdy>
      <sec>
         <st>
            <p>Introduction</p>
         </st>
         <p>Targeting oxygen delivery in the postoperative period has been shown to reduce hospital length of stay and complications <abbrgrp><abbr bid="B1">1</abbr></abbrgrp>. Using a near-infrared spectroscopy device such as the Inspectra&#8482; 325 allows the measurement of tissue oxygen saturation (STO<sub>2</sub>) noninvasively as well as a rudimentary measure of blood flow beneath the probe. It is plausible, then, that changes in oxygen delivery (DO<sub>2</sub>) during postoperative optimisation may be reflected in changes in STO<sub>2 </sub>and provide a noninvasive surrogate of DO<sub>2</sub>.</p>
      </sec>
      <sec>
         <st>
            <p>Methods</p>
         </st>
         <p>All adult patients admitted to the ICU after surgery who underwent protocolised haemodynamic optimisation were included. All patients had STO<sub>2 </sub>recorded over the thenar eminence using an Inspectra&#8482; 325 for the first 8 hours of their stay.</p>
      </sec>
      <sec>
         <st>
            <p>Results</p>
         </st>
         <p>We found a significant correlation between the changes in STO<sub>2 </sub>and oxygen delivery index (DO2I) over the first 8 hours of intensive care stay (<it>n </it>= 40, correlation coefficient of 0.947, <it>P </it>= 0.0001, Figure <figr fid="F1">1</figr>). We classified patients who achieved DO<sub>2</sub>I > 600 ml/min/m<sup>2 </sup>as responders. These responders had higher STO<sub>2 </sub>values by 3 hours of optimisation, a change that remained significant throughout the duration of the study (Figure <figr fid="F2">2</figr>).</p>
         <fig id="F1">
            <title>
               <p>Figure 1</p>
            </title>
            <caption>
               <p/>
            </caption>
            <text>
               <p/>
            </text>
            <graphic file="cc5431-1"/>
         </fig>
         <fig id="F2">
            <title>
               <p>Figure 2</p>
            </title>
            <caption>
               <p/>
            </caption>
            <text>
               <p/>
            </text>
            <graphic file="cc5431-2"/>
         </fig>
      </sec>
      <sec>
         <st>
            <p>Conclusion</p>
         </st>
         <p>Changes in STO<sub>2 </sub>during postoperative optimisation appear to mirror changes in DO<sub>2</sub>I and may allow more widespread use of noninvasive tissue oxygenation devices in surgical optimisation.</p>
      </sec>
   </bdy>
   <bm>
      <refgrp>
         <bibl id="B1">
            <title>
               <p>Early goal-directed therapy after major surgery reduces complications and duration of hospital stay</p>
            </title>
            <aug>
               <au>
                  <snm>Pearse</snm>
                  <fnm/>
               </au>
               <etal/>
            </aug>
            <source>Crit Care</source>
            <pubdate>2005</pubdate>
            <volume>9</volume>
            <fpage>R687</fpage>
            <lpage>R693</lpage>
            <xrefbib>
               <pubidlist>
                  <pubid idtype="pmcid">1414018</pubid>
                  <pubid idtype="pmpid" link="fulltext">16356219</pubid>
                  <pubid idtype="doi">10.1186/cc3887</pubid>
               </pubidlist>
            </xrefbib>
         </bibl>
      </refgrp>
   </bm>
</art>

