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Assessing glomerular filtration rate (GFR) in critically ill patients with acute kidney injury - true GFR versus urinary creatinine clearance and estimating equations

Gudrun Bragadottir, Bengt Redfors and Sven-Erik Ricksten

Critical Care 2013, 17:R108  doi:10.1186/cc12777

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Fascinating study which may have more stories to tell

John Pickering   (2013-06-27 10:22)  University of Otago Christchurch email

Congratulations to the authors on this fascinating study. We have been waiting a long time for someone to attempt true GFR measurements on AKI patients, not an easy task.

The authors note that creatinine clearance may be overestimated because of secretion of creatinine. Studies involving the use of cimetidine seem to confirm this, at least for patients in steady state. However, I wonder if the data presented here may contradict that, or at least fail to confirm it? I took the liberty to run a statistical test comparing the GFR (51Cr-EDTA) with the CrCl data from table 2 (Wilcoxon matched pairs sign rank test) and found that there was no difference. Also the bias (Figure 1) was small and favoured a greater GFR51.

The authors considered if loss of muscle mass resulting in loss of creatinine production may in part explain the poor performance of estimating equations. We��ve noted recently that post cardiac attack there is a potential very rapid loss of creatinine production, probably much more rapid than that of muscle loss (Pickering et al Crit Care 2013:R7).

Finally, our own work on 4 hour creatinine clearance related to AKI suggested some potential clinical utility (Pickering et al Crit Care 2012:R107). I wonder if the authors would like to make some comment concerning to what extent the clinical utility of creatinine clearance may be limited by the duration of urine collection?


John Pickering

Competing interests

No competing interests


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