Target blood pressure in sepsis: between a rock and a hard place
Department of Intensive Care Medicine, Inselspital, Bern University Hospital and University of Bern, Freiburgstrasse 10. CH-3010, Bern, Switzerland
Critical Care 2013, 17:433 doi:10.1186/cc12692
See related commentary by Beloncle et al., http://ccforum.com/content/17/2/126 and related research by Corrêa et al., http://ccforum.com/content/17/1/R21Published: 17 May 2013
First paragraph (this article has no abstract)
We acknowledge the constructive comments of Beloncle and colleagues  regarding our recently published study. We demonstrated that targeting a mean arterial blood pressure (MAP) between 50 and 60 mmHg (Low-MAP) in porcine fecal peritonitis was associated with increased incidence of acute kidney injury (AKI) in comparison to targeting a MAP between 75 and 85 mmHg (High-MAP), which resulted in increased net positive fluid balance and vasopressor load .