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Highly Accessed Open Badges Letter

Target blood pressure in sepsis: between a rock and a hard place

Thiago Domingos Corrêa, Jukka Takala and Stephan Mathias Jakob*

Author Affiliations

Department of Intensive Care Medicine, Inselspital, Bern University Hospital and University of Bern, Freiburgstrasse 10. CH-3010, Bern, Switzerland

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Critical Care 2013, 17:433  doi:10.1186/cc12692

See related commentary by Beloncle et al., and related research by Corrêa et al.,

Published: 17 May 2013

First paragraph (this article has no abstract)

We acknowledge the constructive comments of Beloncle and colleagues [1] regarding our recently published study. We demonstrated that targeting a mean arterial blood pressure (MAP) between 50 and 60 mmHg (Low-MAP) in porcine fecal peritonitis was associated with increased incidence of acute kidney injury (AKI) in comparison to targeting a MAP between 75 and 85 mmHg (High-MAP), which resulted in increased net positive fluid balance and vasopressor load [2].