Hypercapnia and ventilator-induced diaphragmatic dysfunction
1 Department of Anesthesiology and Perioperative Medicine, University of Louisville, 530 S. Jackson Street, Louisville, KY 40202, USA
2 Outcomes Research™ Consortium, Cleveland, OH 44195, USA
Critical Care 2013, 17:129 doi:10.1186/cc12563
See related research by Jung et al., http://ccforum.com/content/17/1/R15Published: 8 April 2013
In the previous issue of Critical Care, Jung and colleagues report on the preventive effects of hypercapnia on ventilator-induced diaphragmatic dysfunction (VIDD) under controlled ventilation. Possibly, a combination of controlled hypercapnia and allowed spontaneous breathing efforts may provide complementary protection for diaphragm and respiratory functionality during mechanical ventilation. However, further safety and efficacy studies need to be performed in various different animal models and patients before a universal application of hypercapnia in the critical care setting for the prevention of VIDD can be considered.