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Highly Accessed Open Badges Commentary

Hypercapnia and ventilator-induced diaphragmatic dysfunction

Ozan Akca12* and Alexander Bautista1

Author Affiliations

1 Department of Anesthesiology and Perioperative Medicine, University of Louisville, 530 S. Jackson Street, Louisville, KY 40202, USA

2 Outcomes Researchâ„¢ Consortium, Cleveland, OH 44195, USA

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Critical Care 2013, 17:129  doi:10.1186/cc12563

See related research by Jung et al.,

Published: 8 April 2013


In the previous issue of Critical Care, Jung and colleagues report on the preventive effects of hypercapnia on ventilator-induced diaphragmatic dysfunction (VIDD) under controlled ventilation. Possibly, a combination of controlled hypercapnia and allowed spontaneous breathing efforts may provide complementary protection for diaphragm and respiratory functionality during mechanical ventilation. However, further safety and efficacy studies need to be performed in various different animal models and patients before a universal application of hypercapnia in the critical care setting for the prevention of VIDD can be considered.