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Highly Accessed Open Badges Commentary

Emerging concepts in optimizing antimicrobial therapy of septic shock: speed is life but a hammer helps too

Anand Kumar1* and Shravan Kethireddy2

Author Affiliations

1 Sections of Critical Care Medicine and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada R3A-1R9

2 Departments of Critical Care Medicine and Infectious Diseases, Geisinger Medical Center, Danville, PA 07822, USA

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Critical Care 2013, 17:104  doi:10.1186/cc11890

See related research by Diaz-Martin et al.,

Published: 15 January 2013


Current research suggests that combination antimicrobial therapy where a given pathogen is covered by two or more antibiotics with differing antimicrobial mechanisms may be useful in a subset of critically ill patients, particularly those with septic shock. This paper elucidates the circumstances under which combination therapy may be useful by reinforcing the observation that beneficial effects are noted in critically ill patients with septic shock and, possibly, severe sepsis. Clinicians may wish to consider this approach with such patients.