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Highly Accessed Open Badges Commentary

RIFLE is alive: long live RIFLE

Zaccaria Ricci

Author Affiliations

Pediatric Cardiac Anesthesia/Intensive Care Unit, Department of Pediatric Cardiology and Cardiac Surgery, Bambino Gesù Children's Hospital, IRCCS, Piazza S. Onofrio 4, 00165, Rome, Italy

Critical Care 2012, 16:182  doi:10.1186/cc11851

See related research by Wlodzimirow et al.,

Published: 29 November 2012


Diagnosis and classification of acute kidney injury was addressed systematically only 8 years ago when the classification called RIFLE (acronym of Risk, Injury, Failure, Loss of function and End stage Kidney disease describing progressive severity of renal damage) was created. Since then, several studies have tried to apply, validate, criticize and modify this initial scheme: as a matter of fact, RIFLE is today one of the most appreciated and utilized medical classification systems worldwide. After an initial period of epidemiological research, it is acceptable to apply it now at the bedside, following both urine output and creatinine criteria, with the purpose of routinely monitoring renal function of critically ill patients.