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Open Badges Commentary

A lipid mediator controls neutrophil recruitment in acute lung injury - should we really be surprised?

Zbigniew Zasłona and Marc Peters-Golden*

Author Affiliations

Department of Internal Medicine, Division of Pulmonary and Critical Care, Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-5642, USA

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Critical Care 2012, 16:161  doi:10.1186/cc11519

See related research by Rossaint et al.,

Published: 25 October 2012


New therapeutic approaches are sorely needed for acute lung injury. Neutrophil recruitment is a pathological hallmark of this syndrome, and is mainly regulated by CXC chemokine receptor 2 and its ligand CXC ligand 1. Rossaint and colleagues have described a new mechanism for regulation of this axis by 12/15-lipoxygenase products. This work opens the door for new therapeutic approaches and highlights the crucial interplay between lipid mediators and chemokines, a time-honored but often-ignored concept.