Measurement of monocyte apoptosis, plasma IL-1β and PR3 activity as an approach to evaluate the immunological status in sepsis
Department of Critical Care Medicine and Respiratory Intensive Care Unit, RuiJin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 The Second RuiJin Road, 200025 Shanghai, China
Critical Care 2011, 15:434 doi:10.1186/cc10248
See related research by Giamarellos-Bourboulis et al., http://ccforum.com/content/15/1/R27 and related commentary by Frazier, http://ccforum.com/content/15/1/124Published: 28 June 2011
First paragraph (this article has no abstract)
In a previous issue of Critical Care, Giamarellos-Bourboulis and colleagues published an article in which they drew a conclusion that inhibition of caspase-1 and defective IL-1β production is an important immunological feature in sepsis . Based on the knowledge of previous research, we would like to make some remarks.