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Time course of haemodynamic parameters, inspiratory plateau airway pressure, arterial blood pH, PaO2 and PaCO2 after oleic acid injection and during a decremental PEEP trial from 20 to 0 cm H2O. |
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| HR (beats/min) |
Mean AP (mmHg) |
pH |
PaO2 (mmHg) |
PaCO2 (mmHg) |
Inspiratory plateau pressure (cm H2O) |
|
|
|
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| ARDS |
129 ± 3 |
75 ± 16 |
7.32 ± 0.06 |
52 ± 5 |
54 ± 5 |
20 ± 1 |
| ARDS20 |
132 ± 4 |
66 ± 13 |
7.33 ± 0.04 |
172 ± 15* |
54 ± 3 |
36 ± 3* |
| ARDS15 |
134 ± 4 |
73 ± 13 |
7.38 ± 0.02 |
175 ± 17* |
54 ± 2 |
26 ± 1* |
| ARDS10 |
145 ± 3* |
75 ± 9 |
7.28 ± 0.05 |
89 ± 19* |
56 ± 5 |
23 ± 2 |
| ARDS5 |
165 ± 10* |
118 ± 9* |
7.33 ± 0.02 |
52 ± 4* |
59 ± 2 |
22 ± 2 |
| ARDS0 |
153 ± 7* |
101 ± 5* |
7.3 ± 0.03 |
52 ± 4* |
62 ± 3* |
21 ± 2 |
|
Data are presented as mean ± standard error of the mean. Measurements were obtained 120 min after oleic acid injection at a PEEP of 5 cm H2O (ARDS) and during a decremential PEEP trial (ARDS20, ARDS15, ARDS10, ARDS5, ARDS0). Each PEEP level was maintained for 15 min before each measurement to allow for haemodynamic and respiratory stabilisation. ARDS, acute respiratory distress syndrome; HR, heart rate; mean AP, mean systemic arterial pressure; PEEP, positive end-expiratory pressure. * p < 0.05 versus ARDS | ||||||
Lambermont et al. Critical Care 2008 12:R91 doi:10.1186/cc6961 |
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